【摘要】 目的:探讨脱氢表雄酮(DHEA)对卵巢储备功能降低(DOR)患者行体外受精-胚胎移植(IVF-ET)治疗结局的影响。方法:对接受体外受精/卵胞浆内单精子注射(IVF/ICSI)助孕治疗的47例DOR患者DHEA辅助治疗前后周期进行自身对照研究,分析卵巢储备功能指标(基础激素水平、窦卵泡计数等)及周期治疗参数(卵泡数、获卵数、受精率、卵裂率、胚胎种植率、临床妊娠率、周期取消率、流产率等)的变化。结果:前后周期超促排卵方案无显著性差异,DHEA辅助治疗后基础窦卵泡计数、卵泡数、获卵数显著增加(P<0.05),卵裂率、胚胎种植率、临床妊娠率显著提高(P<0.05),周期取消率呈降低趋势(P>0.05),而受精率、流产率无差异(P>0.05)。结论:DHEA辅助治疗可以改善DOR患者卵巢储备功能,提高卵巢反应性,改善IVF治疗结局。更多还原

【Abstract】 Objective:To investigate the effect of dehydroepiandrosterone(DHEA) supplementation on in vitro fertilization and embryo transfer(IVF-ET) outcomes among the patients with diminished ovarian reserve(DOR).Methods:A self-control study was conducted on 47 DOR patients treated with IVF/ICSI from Jan 2007 to Aug 2012 in our center.The parameters of ovarian reserve and IVF outcomes between the cycles before and after DHEA treatment were compared,including basal hormone levels,antral follicle count(AFC),the number of follicles,the number of oocytes retrieved,fertilization rate,cleavage rate,implantation rate,clinical pregnancy rate,the cycle cancellation rate and abortion rate.Results:The ovarian stimulation protocols were similar between the cycles with and without DHEA treatment.A significant increase was noted in AFC,number of follicles and retrieved oocytes after DHEA treatment(P<0.05),and cleavage rate,implantation rate and clinical pregnancy rate were improved significantly as well(P<0.05).There was no significant difference in fertilization rate,abortion rate or cycle cancellation rate(P>0.05),but there was a trend towards a reduced cycle cancellation rate after DHEA treatment.Conclusion:DHEA treatment has a beneficial effect on the DOR patients,and could enhance ovarian response and improve the clinical outcome.更多还原