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γ活性与常用闭合型活性宫内节育器比较的meta分析

A meta-analysis of active γ-IUD and other common closed-model IUDs

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【作者】 丛捷王琨邹燕吴尚纯王晨

【Author】 Cong Jie,Wang Kun,Zou Yan,Wu Shangchun,Wang Chen National Research Institute for Family Planning,Beijing 10081

【机构】 国家人口计生委科学技术研究所

【摘要】 目的:运用循证医学系统评价方法比较活性γ型宫内节育器(IUD)与常用闭合型IUD的有效性。方法:检索8种医学数据库和9种相关杂志,并追查参考文献。由2位评价员根据纳入和排除标准筛查检索的文献,并进行meta分析。结果:纳入9篇文献,6299例进行分析,γ活性IUD与活性165IUD比较,在随访2、3年时累计带器妊娠率更低,合并OR及95%CI分别为0.36(0.19~0.70)和0.43(0.20~0.91)。随访1~5年的累计意外妊娠率和累计脱落率均更低,差异均有统计学意义,5年内的累计因症取出率相似。与宫铜200IUD比较,随访1年时,二者带器妊娠和脱落率相似,但γ活性IUD的因症取出率低于宫铜200。与宫铜300IUD比较,随访1年其累计带器妊娠率、累计脱落率和累计因症取出率低。结论:γ活性IUD与常用闭合型IUD相比具优势,值得推广使用。

【Abstract】 Objective:To compare the effectiveness of activeγ-IUD with common closed-model IUDs.Methods:Twelve medical databases and nine related journals were searched.And references of original articles were investigated.All literature were screened according to the inclusion and exclusion criteria by two reviewers,and a meta-analysis was performed.Results:Nine literatures were included,and 6 229 cases were meta-analyzed.Compared with active 165 IUD,the two and three-year cumulative pregnancy rates with IUD in situ ofγ-UD were lower,with the OR and 95%CI were 0.36(0.19-0.70)and 0.43(0.20-0.91).One-to five-year follow-up reveals that the cumulative unexpected pregnancy rate and cumulative expulsion rate were significantly lower,and the five-year cumulative discontinue rate for medical reasons of both IUDs was similar.Compared with GT200 IUD,1-year follow-up found that the discontinue rate for medical reason of active γ-IUD was lower,while the pregnancy rate with IUD in situ and expulsion rate of both IUDs were similar.Moreover,compared with GT300 IUD,the one-year cumulative pregnancy rate with IUD in situ,cumulative expulsion rate and cumulative discontinue rate for medical reason of activeγ-IUD were lower.Conclusion:Activeγ-IUD is worth using widely.

【关键词】 活性γ型宫内节育器有效性meta分析
【Key words】 Active γ-IUDEffectivenessMeta-analysis
【基金】 国家十五科技攻关课题资助(2004BA720A31)
  • 【文献出处】 中国计划生育学杂志 ,Chinese Journal of Family Planning , 编辑部邮箱 ,2012年06期
  • 【分类号】R169.4
  • 【被引频次】6
  • 【下载频次】79
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