【摘要】 低功率激光(632.8 nm)照射(Low-power laser irradiation,LPLI)生物组织作为一种无损伤的物理疗法,可以加速细胞生长、血管再生及伤口愈合等过程。一氧化氮(Nitric oxide,NO)是伤口愈合的关键因素之一,其促进炎性细胞的趋化,增强胶原的合成和沉积,刺激细胞增殖和新生血管生成。我们研究发现LPLI可以促进NO的产生,并且抑制细胞外调节蛋白激酶(Extracellular signal-regulated protein kinases,ERK)的活性阻碍了NO的产生,证明LPLI通过活化ERK调控NO的生成。这一研究将为低功率激光照射加速伤口愈合在临床上的应用奠定基础。更多还原

【Abstract】 Low-power laser irradiation(LPLI),as a non-damage physical therapy,acclerrates cell survival,angiogenesis and wound healing in which nitric oxide(NO) acts as an important contributor.NO promotes the tendency of inflammation cell,increases the synthesis and precipitation of collagen,and stimulates cell proliferation and angiogenesis.In this study,we found that LPLI boosted the production of NO,which was inhibited by blocking ERK(Extracellular signal-regulated protein kinase,ERK) activation,indicating LPLI promoted NO generation through activating ERK.The research will supply potential strategy for the clinical application of LPLI in the treatment of wound healing.更多还原