【摘要】 目的探索小鼠60Coγ射线损伤后造血系统各项生理指标的变化规律。方法采用60Coγ射线对小鼠进行一次性全身照射,剂量分别为2、4、6 Gy,在不同时间分别测定小鼠体质量,外周血细胞计数,免疫器官指数及股骨骨髓的病理变化。结果照射后小鼠的外周血象有变化,其中白细胞下降最迅速且明显,其次是血小板,且具有剂量效应关系。照射后3 d免疫器官指数下降明显,与对照组比较具有显著性差异;骨髓造血细胞数目迅速减少,出现造血抑制;照射后小鼠体质量增加缓慢,但与对照组比较无显著性差异。结论60Coγ射线照射可引起小鼠外周血细胞下降,免疫器官指数下降,并抑制骨髓造血细胞增生。更多还原

【Abstract】 Objective To explore the physiological variation of the hematopoietic system in mice after 60Coγ ray irradiation.Methods Body weight,peripheral blood cell counts,the immune organ index and pathological changes in femoral bone marrow of mice were measured at different times after whole-body irradiation with 60Coγ ray.The doses were 2,4,6 Gy respectively.Results The changes of peripheral blood of mice were different.The white blood cell counts declined most rapidly and obviously,followed by the platelet count,with a dose-effect relationship.Three days after radiation,the immune organ index of mice decreased significantly compared with the immune organ index in mice unirradiated.Myeloid elements in bone marrow were reduced and bone marrow hematopoiesis was depressed.Body weight of irradiated mice grew slowly,without significant difference with mice unirradiated.Conclusion 60Coγ ray radiation can decrease peripheral blood cells,decrease the immune organ index and inhibit bone marrow cell proliferation in mice.更多还原