【摘要】 目的肺动脉高压(pulmonary arterial hypertention,PAH)是左向右分流型先天性心脏病(congenital heart disease,CHD)常见且严重的并发症,是影响先心病外科治疗效果的重要因素,本文探讨西地那非治疗CHD合并PAH的临床治疗效果。方法研究对象为2009年8月至2011年3月我院收治的20例心内左向右分流、平均肺动脉平均压>25mmHg的CHD患者,给予西地那非口服,一次20mg,每6小时一次,对比用药前后患者平均肺动脉平均压力的变化。结果西地那非连续使用5d后,患者平均肺动脉压力明显下降。结论在CHD合并PAH的治疗中,西地那非可以特异地降低肺动脉压力,改善心功能,降低死亡率,其使用方便,可为CHD合并PAH治疗的首选。更多还原

【Abstract】 Objective Pulmonary hypertension(PAH) is a fairly common and serious leisure succeed to congenital heart disease(CHD),it is a important agent to affect surgical therapeutic efficacy.To investigate the clinical efficacy of sildenafil citrate for treatment with PAH secondary to CHD.Methods we randomly assigned 20 patients with intracardiac left-to-right shunt and pulmonary artery mean pressure>25 mmHg to sildenafil citrate(20mg) orally one time every 6h.We measure the Pulmonary artery Pressure(PAP) before medication and on operation.Results The PAP on operation were lower than before medieation(P <0.01).Conclusions It Prompt that Sildenafil citrate can reduce pressure of pulmonary artery and improve heart function.更多还原