【摘要】 目的评价抗环瓜氨酸肽(CCP)抗体、6-磷酸葡萄糖异构酶(GPI)、类风湿因子(RF)对类风湿关节炎(RA)的诊断价值。方法检测148例RA患者组、126例其他自身免疫性疾病患者组和110例正常对照组血清中RF(速率散射比浊法)、抗CCP抗体(ELISA法)和GPI(ELISA法),比较分析其检测结果一致性和对RA的诊断效率。结果 RA患者组抗CCP抗体和GPI的平均浓度显著高于自身免疫病患者组和正常对照组(P<0.05),抗CCP和GPI对RA诊断的特异性高于RF(P<0.05)。2种或3种指标联合检测对RA诊断的敏感性减低,但其特异性高于单项检测指标(P<0.05)。结论抗CCP抗体和抗GPI均是RA敏感而特异性血清学指标,两者与RF综合分析,有助于RA的早期诊断,并提高RA的诊断效率。更多还原

【Abstract】 Objective To evaluate the clinical signification of rheumatoid factor(RF),anti-cyclic citrullinated peptide(CCP) antibody and glucose-6-phosphate isomerase(GPI).Methods Sera from 148 patients with RA,126 patients with autoimmune diseases and from 110 healthy control subjects were investigated by ELISA examining anti-CCP and GPI,rate nephelometry method measuring RF.The consistency of their clinical significance and efficiency in the diagnosis of RA were intercompared.Results In RA patients,the mean seru concentration of CCP and GPI was higher than that in patients with autoimmune diseases and the healthy people(P<0.05).The specificity of CCP and GPI was higher than RF in the diagnosis of RA(P<0.05).In combination with 2 index or 3 index,the sensitivity of combination was lower,yet the specificity was higher(P<0.05).Conclusion Anti-CCP and GPI are sensitive and specific serological markers for RA,to associate result of anti-CCP and GPI with RF can be helpful for diagnosis of early RA and enhance the efficiency in diagnosis of RA.更多还原