【摘要】 目的研究血管内皮细胞生长因子-C(vascular endothelail growth factor-C,VEGF-C)在皮肤恶性黑素瘤(cutaneous malignant melanoma,CMM)中的表达。方法应用免疫组化S-P法检测血管内皮细胞生长因子-C在交界痣30例、皮肤恶性黑素瘤30例及15例正常皮肤组织中的表达。结果皮肤恶性黑素瘤中血管内皮细胞生长因子-C的阳性表达率明显高于交界痣和正常对照组(P<0.05),交界痣与正常对照组相比,无显著性差异(P>0.05)。结论血管内皮细胞生长因子-C的高表达可能与皮肤恶性黑素瘤的发生发展有关,有望作为临床治疗黑素瘤的突破点。更多还原

【Abstract】 Objective To investigate the expression of vascular endothelial growth factor-c(VEGF-C) protein in cutaneous malignant melanoma(CMM) and its significance.Methods The expression of VEGF-C protein in 30 specimens of CMM,30 specimens of junctional nevus and 15 specimens of normal skin tissues were detected by immunohistochemical S-P method.Results The positive-expression rate of VEGF-C protein in CMM was significantly higher than that in junctional nevus and normal skin tissues(P<0.05).However there is no significant difference positive-expression rate of VEGF-C between the latter two groups(junctional nevus and normal skin tissues)(P>0.05).Conclusions High expression of VEGF-C protein may play a potential role in the pathogenesis of CMM.Therefore,VEGF-C protein may have significant therapeutic implications as molecular target.更多还原