【摘要】 目的观察螺旋藻治疗不同中医辩证分型幽门螺杆菌(H.pylori)阳性慢性胃炎的临床疗效及其安全性。方法364例H.pylori阳性的慢性胃炎患者随机进入治疗组和对照组,对照组分别予以阿莫西林或阿莫西林-克拉维酸钾进行标准三联H.pylori根治,治疗组在此基础上给予螺旋藻,5周为一疗程。观察并记录治疗前后腹痛或腹部不适、烧心、反酸、腹胀、嗳气情况。治疗结束4周后,采用13 C-UBT法检测H.pylori根除率,并采用PP分析和ITT分析方法进行评估。结果治疗后治疗组和对照组在腹痛或腹部不适、烧心及反酸单一症状缓解程度上均显著优于治疗前(P<0.05),而腹胀和嗳气在治疗前后均无明显改善。治疗组的总体疗效亦显著优于对照组(P<0.05),ITT分析为88.7%vs 78.6%,76.3%;PP分析为89.1%vs 78.9%,75.0%)。治疗组与对照组之间以及不同中医证型之间H.pylori根除率无显著差异。结论螺旋藻在不同中医辩证分型H.pylori阳性慢性胃炎中疗效肯定,安全性较好。更多还原

【Abstract】 Objective To observe the effects and safety of Spirulina on treating Helicobacter pylori-positive chronic gastritis(HPCG) with different traditional Chinese medicine(TCM) syndromes.Methods Totally 364 HPCG cases with different TCM syndromes were randomized into trial group and control groups.The control groups were treated with amoxicillin or amoxicillin-clavulanate potassium-based rountine H.pylori eradication.Trial group was treated with spirulina and amoxicillin-based rountine H.pylori eradication.Patients’ symptoms,such as abdominal pain,discomfort,and heart burn,acid regurgitation,distension and belching were recorded before and after treatment.H.pylori eradication rates were detected.Results Efficacy assessment on symptoms showed that individual symptom between pre-and post-treatment was different statistically in treatment group and the control groups(P<0.05),except for distension and belching.The total effective rate in the treatment group was better than those in the control groups(P<0.05,ITT analysis:88.7% vs 78.6%,76.3%;PP analysis:89.1% vs 78.9%,75.0%).There was no significant difference statistically of H.pylori eradication rates between the three groups and between different TCM syndrome typing groups.Conclusion Spirulina is effective and safe for HPCG patients with different TCM syndromes.更多还原