【摘要】 探讨了海洋中常见药残磺胺嘧啶(SD)和磺胺甲恶唑(SMX)对球形棕囊藻和东海原甲藻生长的影响。结果表明:当这两种磺胺药物浓度大于20 mg/L时,球形棕囊藻和东海原甲藻的生长明显被抑制;SD和SMX对球形棕囊藻半数生长影响的浓度(EC50)分别为60～80 mg/L和20～40 mg/L;SD和SMX对东海原甲藻半数生长影响的浓度分别为20～40 mg/L和40～60 mg/L;两种藻培养96 h时扫描电镜观察,均显示高浓度下藻细胞膜严重破损,说明磺胺药物对其生长具有抑制作用。EC50对比表明球形棕囊藻对SD的耐受性强于SMX,而东海原甲藻对SMX的耐受性强于SD。两种藻对药残的耐受性明显强于其他藻种,在高浓度药残环境中占据生存优势。通过这项研究,试图探讨磺胺药物对河口及近海养殖区赤潮频发和赤潮消亡的影响。更多还原

【Abstract】 The aim of this work was to study the effect of sulfadiazine(SD) and sulfamethoxazole(SMX) on the growth of Phaeocystis globosa and Prorocentrum donghaiense.The results showed that both of P.globosa and P.donghaiense were obviously inhibited when the concentration of SD and SMX climbed over 20 mg/L.The EC50 of SD and SMX on P.globosa were 60~80 mg/L and 20~40 mg/L,respectively,while the EC50 of SD and SMX on P.donghaiense were 20~40 mg/L and 40~60 mg/L.The algae cell membrane observed by scanning electron microscopy(SEM) at 96 h was seriously damaged at a high concentration,so sulfa drugs could cause the inhibition of red tide.The comparison of EC50 showed that P.globosa had the stronger tolerance to SD than SMX,but P.donghaiense had the weaker tolerance to SD than SMX,P.globosa and P.donghaiense had the stronger tolerance to drug residues than other algae which had advantage to survival in the high drug residues environment.Through this research,the influence of sulfa drugs on the growth of red tide which broke out in estuaries and culture zones adjacent sea areas was attempted to study.更多还原