【摘要】 目的评价铜绿假单胞菌注射液(万特普安)联合奈达铂腹腔灌注化疗对复发卵巢癌腹水的疗效。方法复发卵巢癌患者86例,试验组42例,对照组44例,两组采用相同的化疗方案,试验组加用铜绿假单胞菌注射液。治疗结束后评价疗效,并在治疗前后分别检测患者的毒性反应和其他指标的变化情况。结果试验组治疗前后及试验组和对照组治疗后分别进行Karnofsky评分比较,发现试验组治疗后患者的体力状况明显改善(P<0.0001);试验组的总缓解率(RR)高于对照组,但差异无统计学意义;试验组复发卵巢癌患者腹水在化疗第4个疗程后全部消失;而对照组在化疗第4个疗程后仅有59.1%的患者腹水消失且6个疗程化疗完成后仍有3例腹水未消失,与对照组比较差异有统计学意义(P<0.05)。结论应用万特普安联合奈达铂腹腔化疗治疗复发卵巢癌恶性腹水明显有效,同时全身症状明显改善,毒副作用低。更多还原

【Abstract】 Objective To evaluate the effect of intraperitoneal chemotherapy with Pseudomonas aeruginosa injection(Wan Te Puan) combined nedaplatin for the ascites of recurrent ovarian cancer.Methods Eighty-six patients with recurrent ovarian cancer patients(42 patients in the experimental group and 44 patients in the control group) were included.All the groups applied the same chemotherapy,and the experimental group was injected with Pseudomonas aeruginosa.After the evaluation of treatment efficacy,toxicity and changes of other indicators of patients were measured before and after treatment.Results The patients’ physical status after treatment in the experimental group was significantly improved(P<0.0001).Overall response rate(RR) in the test group was higher but without statistical significance.The ascites in test group were completely disappeared in all ovarian cancer patients after the fourth courses of chemotherapy,but only 59.1% were disappeared in the control group.After the six courses of chemotherapy,3 cases did not disappear.There were statistically significant between the two groups(P<0.05).Conclusion Wan Te Puan combined nedaplatin for recurrent ovarian cancer has obvious effect and low toxicity,and systemic symptom is significantly improved.更多还原