【摘要】 目的探讨尤瑞克林对不同结构性影像类型进展性脑梗死的CT与临床效果。方法 2007年3月-2011年6月按入院时不同结构性影像类型将进展性脑梗死分为大灶梗死、中灶梗死、小灶梗死及腔隙梗死4型,共235例,采用分层随机分组的方法将患者分为尤瑞克林组(治疗组)119例,对照组116例。两组基础用药均为疏血通6 mL+生理盐水250 mL静脉滴注,胞磷胆碱0.5 g+生理盐水250 mL静脉滴注,阿司匹林0.1 g口服,以上用药均为1次/d,连用4周。治疗组同时给予生理盐水100 mL+尤瑞克林0.15 PNAu静脉滴注,对照组同时给予生理盐水100 mL静脉滴注,1次/d,连用7～14 d,两组治疗前后均测量梗死的最大层面最大梗死灶的长度与宽度,计算并记录梗死面积;统计分析各型的临床疗效。结果①梗死面积改变:治疗前各亚型治疗组与对照组梗死面积差异均无统计学意义(P>0.05);治疗后,大灶梗死组、中灶梗死组、小灶梗死组中的治疗组梗死面积均比治疗前显著缩小(P<0.01),而对照组的梗死面积较治疗前差异无统计学意义(P>0.05);腔隙梗死组中,治疗组及对照组治疗后梗死面积均无明显改变(P>0.05)。②临床疗效:各亚型进展性脑梗死,治疗组均取得优于对照组的效果;大灶梗死及中灶梗死的显著进步率分别为47.6%和66.7%,而对照组的显著进步率分别为0.0%和33.3%。结论大灶梗死组、中灶梗死组、小灶梗死组进展性脑梗死使用尤瑞克林治疗后梗死面积均比治疗前明显缩小;各亚型进展性脑梗死使用尤瑞克林后临床疗效均优于对照组,尤其是大灶梗死及中灶梗死的临床效果更加显著。更多还原

【Abstract】 Objective To investigate CT and the clinical effect of urinary Kallidinogenase on acute progressive cerebral infarction in different imageology styles.Methods A total of 235 patients were admitted into the hospital because of cerebral infarction between March 2007 and June 2011.They were divided into four subgroups according to different imageology styles: large infarct,middle infarct,small infarct and lacunar infarct.These patients were randomly divided into two groups: treatment group where the patients were treated with urinary Kallidinogenase(n=119) and control group(n=116).The basic medicine for both the two groups was intravenous injection of Shuxuetong 6 ml,Citicoline 0.5 g and Aspirin 0.1 g per day for four weeks.Patients in the treatment group were at the same time administered intravenous injection of urinary Kallidinogenase 0.15 PNAu,and patients in the control group were administered sodium chloride once per day for 7-14 days.The primary length and width of the largest infarction were measured and the infarct size was calculated in the two groups.Then,clinical effect for all the four types was analyzed.Results 1.Before treatment,the infarct size had no statistical differences between the treatment group and the control group(P > 0.05).Post-treatment infarct size was significantly smaller in three types of infarct: large,middle,and small infarct(P < 0.01),while the pre-and post-infarct size in the control group had no significant difference(P > 0.05).Lacunar infarct had no significant changes in both the treatment group and the control group(P > 0.05).2.The clinical effect for the treatment group was better than the control group in all the four types.Especially,the effective rate for large infarct and middle infarct was 47.6% and 66.7%,while for the control group,it was 0% and 33.3%.Conclusions Infarct size of large infarct,middle infarct,and small infarct patients becomes significantly smaller by using urinary Kallidinogenase.The clinical effect for all the subtypes of infarct was better than the control group,especially for patients with large and middle infarct.更多还原