【摘要】 目的探讨氯胺酮对兔定量药物脑电图(QPEEG)δ频段功率百分比的影响。方法将24只成年白色家兔随机均分为NS组、KET4组、KET8组及KET16组,分别于耳缘静脉注射NS及4、8、16 mg.kg-1的氯胺酮,观察并比较各组家兔给药前后QPEEGδ频段的功率变化。结果兔静脉注射氯胺酮4、8、16 mg.kg-1后,各脑区的δ频段功率百分比在0.5～5 min内均较给药前明显增加,1～2 min达高峰。在给药后0.5～5 min内随氯胺酮剂量的增大,δ频段功率百分比的增加越明显。结论氯胺酮可剂量依赖性地增加兔QPEEGδ频段的功率百分比,提示QPEEGδ频段功率百分比有可能成为监测氯胺酮麻醉深度的指标。更多还原

【Abstract】 OBJECTIVE To investigate the effects of ketamine on the δ-band power percentage of quantitative pharmaco-EEG(QPEEG) in rabbits.METHODS 24 adult rabbits were randomly divided into 4 groups and were intravenously injected with 4,8,16 mg·kg-1 of ketamine and nomal saline respectively.The power spectral analysis was conducted to check the changes of δ-band power percentage of QPEEG in each group before and after drug infusions.RESULTS After the rabbit was injected,the δ-band power percentage of each brain region significantly increased from 0.5 min to 5 min(P<0.05,P<0.01) and reached its peak between 1 min and 2 min.Moreover,a positive correlation between δ-band power percentage and the doses of ketamine was detected from 0.5 min to 5 min.CONCLUSION Ketamine can increase the δ-band power percentage of QPEEG in a dose-dependent manner,which suggests that δ-band power percentage of QPEEG may be a desired index of the depth of anesthesia monitoring.更多还原