【摘要】 以5-氟尿嘧啶-1-基乙酸为原料,1-乙基-3-(3-二甲基氨基丙基)碳二亚胺盐酸盐(EDCI)为缩合剂,N-羟基苯并三氮唑(BtOH)为辅助试剂,与中间体α-氨基膦酸酯类化合物反应,得到了标题化合物,并经IR,1HNMR,13CNMR,31PNMR和ESI-MS确认了其结构。生物活性测试的结果表明,目标化合物对BEL-7402、HL-60有较弱的抑制作用。更多还原

【Abstract】 The object compound was synthesized from 5-fluorouracil-1-yl acetic acid and the intermediate of α-amino phosphonate with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochioride(EDCI) as condensation reagent and N-hydroxybenzotriazole(HOBt) as auxiliary reagent.The structure was confirmed by IR,1HNMR,13CNMR,31PNMR and ESI-MS.The result of the biological test shows that the compounds 3a,3b have weak antitumor activities to BEL-7402,HL-60.更多还原