【摘要】 2008年从东非大戟科属植物Phyllanthus engleri中分离的吉玛烷型倍半萜(-)-englerin A对6种肾脏癌细胞展示了非常好的抑制活性(GI50:1—87nm),甚至比紫杉醇的抗癌活性高1—2个数量级。这类倍半萜因其结构特点和显著的抗癌活性引起了有机化学界的广泛关注,短短几年之内,就有多条全合成路线先后被报道。本文主要综述了(-)-englerin A及其类似物的合成进展,按照各个研究小组运用的关键策略加以分类,来阐述他们各自的合成特点。更多还原

【Abstract】 In 2008,the guaiane sesquiterpene(-)-englerin A,isolated from the genus phyllanthus engleri in East Africa,selectively inhibited the growth of renal cancer cell lines with GI50 values ranging from 1—87nm.It was found to be 1—2 orders of magnitude more potent than taxol against certain cell lines.The promising bioactivity and the structural complexity of(-)-englerin A and its analogues have attracted many organic chemists all over the world.Many studies toward the total synthesis of englerin A and its analogues were reported in three years.The article reviews the progress on the synthesis of englerin A and its analogues,We classified these syntheses according to key strategies for syntheses of englerin A and its analogues and elaboratted the characteristics of these synthetic routes.更多还原