【摘要】 用12C6+离子束对小鼠进行一次性全身辐照,检测不同剂量的酵母β-葡聚糖对12C6+辐射损伤小鼠免疫系统的防护作用。辐照后观察小鼠的体重、毛色及行为变化,照后第2天和第7天检测小鼠外周血中白细胞含量,照后第8天检测小鼠胸腺和脾脏内SOD,GSH-PX活性和MDA含量。实验结果表明,给予酵母β-葡聚糖能减缓辐照引起的小鼠体重急剧下降,增加小鼠外周血中白细胞含量,不同程度地恢复胸腺和脾脏SOD和GSH-PX活性,降低胸腺和脾脏MDA含量。表明酵母β-葡聚糖对12C6+引起的小鼠辐射损伤具有防护作用。更多还原

【Abstract】 To detect Yeast β-glucan ’s protective effect on mice ’s immune system after C ion beam radiation,mice were used as the test model.We observed the weight,hair color and behavior of mice everyday within a 7dperiod of time after irradiation.Meanwhile,the content of white blood cell,on the 2nd and 7th day after irradiation was detected.We detected the thymus and spleen SOD,GSH-PX activity and MDA content of the mice on the 8th day.The results showed that yeast β-glucan could reduce the rapid weight loss of mice,increase white blood cell content,increase thymus and spleen SOD,GSH-PX activity,decrease MDA content of thymus and spleen.These results indicate that yeast β-glucan can protect mice ’ s immune system against C ion beam radiation damage.更多还原