【摘要】 目的:了解腹膜透析患者脂代谢紊乱与微炎症状态的关系。方法:对60例尿毒症患者腹膜透析前、透析1a内血甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、脂蛋白(a)、载脂蛋白A1(apoA1)、载脂蛋白B(apoB)、血浆白蛋白(Alb)及高敏C反应蛋白(hs-CRP)、IL-6进行检测。60例健康体检者为对照。结果:腹膜透析患者透析前TG、脂蛋白(a)、apoB、hs-CRP、IL-6水平高于对照(t=3.776,2.914,2.309,12.378和11.204,P<0.05),HDL-C和Alb水平低于对照(t=3.285,3.960,P<0.05)。透析过程中,随透析时间的延长,患者血TG、TC、LDL-C、脂蛋白(a)及hs-CRP、IL-6水平均逐渐升高(F=18.953,23.084,14.907,3.394,12.841,3.526,P<0.05),HDL-C水平逐渐降低(F=3.227,P<0.05)。腹膜透析患者透析前血清hs-CRP、IL-6水平与TC、LDL-C和apoB呈正相关(r=0.562～0.871,P<0.05),与Alb呈负相关(r=-0.821和-0.784,P<0.05)。结论:腹膜透析患者存在严重的脂质代谢紊乱及炎症状态,两者可能存在相互作用。更多还原

【Abstract】 Aim:To investigate the serum lipid profiles and microinflammatory state in patients with peritoneal dialysis(PD) and the relationship between them.Methods:Serum lipid and inflammatory factors(hs-CRP and IL-6) levels were determined in 60 patients before and after PD and 60 healthy control.Results:Compared with those in the normal controls,serum TG,LP(a),apoB,hs-CRP,and IL-6 levels increased(t = 3.776,2.914,2.309,12.378 and 11.204,P < 0.05),while serum HDL-C and Alb levels decreased(t = 3.285,3.960,P < 0.05) in PD patients.In the course of PD,serum TG,TC,LDL-C,LP(a),hs-CRP,and IL-6 levels increased gradually(F = 18.953,23.084,14.907,3.394,12.841,3.526,P < 0.05),while serum HDL-C level decreased(F = 3.227,P < 0.05).Serum hs-CRP and IL-6 levels had positive relationship with TC,LDL-C and apoB levels(r = 0.562 ～ 0.871,P < 0.05),and negative relationship with Alb(r =-0.821,-0.784,P < 0.05) in patients before PD.Conclusion:Hyperlipidemia and microinflammatory state are quite common and severe in PD patients,and there may be mutual effect between them.更多还原