【摘要】 目的:探讨联合检测血清胱抑素C(CysC)、脂蛋白(a)水平对早期糖尿病肾病(DN)的诊断价值。方法:采用免疫比浊法分别检测60例早期DN患者(DN组)、55例无肾病的糖尿病患者(NDN组)和50例健康成年人(对照组)血清CysC和脂蛋白(a)水平,并分析比较单项及联合检测对早期DN的诊断效能。结果:DN组血清CysC和脂蛋白(a)水平均高于对照组和NDN组(F=5.888,14.026,P均<0.05);二者诊断DN的灵敏度分别为86.7%和68.3%,特异度分别为95.0%和93.3%,二项指标联合检测灵敏度达91.6%,特异度达91.7%。结论:CysC与脂蛋白(a)联合检测较单项检测能大大提高检测灵敏度,对于早期DN的诊断有重要意义。更多还原

【Abstract】 Aim:To explore the diagnostic value of serum cystatin C(Cys C) and lipoprotein(a) for early diabetic nephropathy(DN).Methods:The immune turbidimetry was used to detect serum Cys C and lipoprotein(a) in 60 cases of patients with early DN(DN group),55 patients without nephropathy but with diabetes mellitus(NDN group),and 50 healthy adults(control group).The efficacy of single index or 2 indexes combined in diagnosis of early DN was compared.Results:Serum Cys C and lipoprotein(a) in early DN group were significantly higher than those in the control group and NDN group(F=5.888,14.026,P<0.05).The sensitivity of Cys C and lipoprotein(a) in diagnosis of DN was 86.7% and 68.3%,specificity was 95.0% and 93.3%,which were 91.6% and 91.7% when the 2 indexes combined.Conclusion:Combined detecting serum Cys C and lipoprotein(a) can greatly improve detection sensitivity of early DN.更多还原