【摘要】 目的:探讨前列腺孤立性肿瘤的临床表现、病理形态学、免疫组化及生物学行为。方法:收集前列腺孤立性纤维肿瘤15例,观察其临床病理特点及免疫组化表型。结果:年龄46～91岁,平均54.5岁。光学显微镜下形态多样,边界清晰,由交替性分布的细胞丰富区和细胞稀疏区组成,分技状的血管外皮瘤样结构;可见黏液变、脂肪细胞形成。免疫表型:几乎所有肿瘤细胞质呈Viment(15/15)、CD34(15/15)强阳性、弥漫表达,CD99(14/15)、Bcl-2(13/15)呈阳性表达。结论:孤立性纤维肿瘤可发生在躯体所有解剖部位,发生在前列腺的孤立性纤维肿需与该处其它梭形细胞肿瘤鉴别诊断,依据其组织学特点及免疫组化表型可作出诊断。更多还原

【Abstract】 ObjectiveTo investigate the clinical manifestation,pathological morphology,and immunohistochemical features of prostatel solitary fibrous tumors(PSFT) and their biologic behaviors.Methods Prostate solitary fibrous tumor in 15 cases were collected to observe their the clinical features and immunohistochemical phenotype.Results Affect age ranged from 46 to 91 years.Histologically,the tumors showed range of growth cellular and patterns,varied from predominantly fibrous lesions containing large collagenized areas to more cellular and less fibrous areas,with thick-walled branching vessels showing HPC-like groeth pattern.Myxiod degeneration and fat-forming areas were noted immunohistochemically,all cases of the tumor cells showed diffusely and strongly positives for both Vimentin(15/15) and CD34(15/15),less frequently positive for CD99(14/15),Bcl-2(13/15).Conclusion SFT are mesenchymal spindle cell tumors which could be found in various sites of human body and need to be distinguished from spindle cell tumors.更多还原