【摘要】 目的观察舍曲林治疗老年人群卒中后抑郁的疗效。方法将100例老年脑卒中后抑郁患者随机分为2组,实验组51例口服盐酸舍曲林片;对照组49例应用三环类抗抑郁药阿米替林片。2组均3个月为1疗程。分别在治疗前及治疗3个月后应用汉密尔顿抑郁量表(hamilton rating scale for depression,HAMD)评分评估抑郁改善情况,采用TESS不良反应量表(treatment emergent symptom scale,TESS)评估不良反应事件,应用NIHSS量表(national institute of health stroke scale)评估患者神经功能缺损恢复情况。结果治疗3个月后,实验组汉密尔顿抑郁量表评分、TESS不良反应量表评分和NIHSS评分均较对照组明显降低,差异有统计学意义(P<0.05)。结论舍曲林治疗老年人群脑卒中后抑郁疗效确切,且不良反应较小,总体评价安全有效。更多还原

【Abstract】 Objective To investigate the therapeutic effects of sertraline for post-stroke depression in elder people.Methods Totally 100 elder patients with post-stroke depression were randomly divided into two groups,the experimental group(using sertraline,n=51) and control group(using amitriptyline,n=49).The total course of experiment was 3 months.After the treatment,we adopted the Hamilton rating scale for depression(HAMD) to measure the improvement of depression symptoms.The treatment emergent symptom scale(TESS) was used to observe the side effects.Moreover,NIHSS was used to measure improvement of the neural function defect.Results Compared with control group,the HAMD scale,TESS scale as well as NIHSS scale in experimental group patients all decreased after 3 months(P<0.05).Conclusion Sertraline is an effective and safe way for post-stroke patients in elderly.更多还原