【摘要】 目的观察希罗达联合奥沙利铂治疗老年晚期结直肠癌的疗效及毒副反应。方法采用希罗达联合奥沙利铂治疗28例老年晚期结直肠癌患者,奥沙利铂130 mg.m-2,d1;希罗达1 000 mg.m-2,连用14d,21 d为1周期,每2周期评价疗效。结果 28例患者中,CR 1例(3.6%),PR 12例(42.9%),SD 11例(39.3%),PD 4例(14.3%),有效率为46.4%,中位肿瘤进展时间为7.3个月。主要毒副反应为骨髓抑制、消化道反应、周围神经毒性、手足综合征。结论希罗达联合奥沙利铂治疗老年晚期结直肠癌有效且安全。更多还原

【Abstract】 Objective To evaluate the efficacy and toxicities of xeloda plus oxaliplatin in the treatment of the elderly patients with advanced colorectal cancer.Methods A total of 28 elderly patients with advanced colorectal cancer received the chemotherapy,oxaliplatin 130 mg·m-2 on day 1;xeloda 1 000 mg·m-2 on days 1-14,every 3 weeks as a cycle,the efficacy was evaluated after 2 cycles of chemotherapy.Results Of the 28 patients,CR was observed in the 1 case(3.6%),PR was observed in the 12 cases(42.9%),SD was observed in the 11 cases(39.3%),PD was observed in the 4 cases(14.3%),the overall response rate was 46.4%,the median time to tumor progress was 7.3 months.The common toxicities were marrow depression,gastrointestinal reaction,peripheral neurotoxicity and hand-foot syndrome.Conclusion The xeloda plus oxaliplatin is effective and safe for the elderly patients with advanced colorectal cancer.更多还原