【摘要】 目的探讨周剂量奥沙利铂(L-OHP)联合替吉奥(S-1)作为一线治疗方案治疗老年晚期胃癌的疗效和安全性。方法 24例有可测量病灶的老年晚期胃癌患者采用L-OHP联合S-1治疗,以3周为1周期,至少连用2周期以上评价疗效和毒副反应。结果全组24例患者均可评价疗效,其中CR 0例,PR 10例,SD 6例,PD 8例,客观有效率为41.67%,疾病控制率66.67%。中位疾病进展时间为5个月。中位缓解期8个月。毒副反应主要是骨髓抑制和恶心呕吐,均为可逆性。结论周剂量L-OHP联合S-1一线治疗老年晚期胃癌的近期疗效肯定,安全性较好。更多还原

【Abstract】 Objective To evaluate the effect and toxicities of weekly oxaliplatin(L-OHP) plus S-1 as a first line chemotherapy regimen for elderly patients with advanced gastric cancer.Methods Twenty-four elderly patients with advanced gastric cancer received the L-OHP plus S-1 chemotherapy,3 weeks were 1 cycle,and the effect and toxicities were evaluated after 2 cycles of chemotherapy.Results Of all the 24 patients could be evaluated,CR was observed in the 0 patient,PR in the 10 patients,SD in the 6 patients,PD in the 8 patients,the overall response rate was 41.67%,the disease control rate was 66.67%.The median time to tumor progression was 5 months.The median duration of remission was 8 months.The major toxicities were bone marrow suppression,nausea and vomiting.Conclusion Weekly oxaliplatin plud S-1 is effective and safe as a first line regimen for elderly patients with advanced gastric cancer.更多还原