【摘要】 以舒必利(SUL)为模板分子,甲基丙烯酸(MAA)为功能单体,乙二醇二甲基丙烯酸酯为交联剂,采用本体聚合法合成了舒必利的分子印迹聚合物(MIP),采用静态平衡和等温吸附实验研究了影响MIP性能的各种因素及吸附机理.结果表明,当SUL为0.3mmol时,制备其MIP的优化条件为:乙腈溶剂用量6mL,SUL与MAA的摩尔比为1:4,以甲醇-乙酸(9:1,?)溶液为洗脱剂洗脱;该聚合物结构均匀、疏松,对SUL具有较好吸附性能,最大吸附容量为79.12μmol/g,印迹因子为3.76;初步认为其吸附机理是SUL分子结构中的N-甲基吡咯烷、酰胺和苯磺酰胺基团上的氨基与MAA自组装形成的吸附识别位点空穴;该MIP能识别SUL及其结构类似物阿米舒必利和泰必利,特异性吸附率分别为68.35%,66.72%和58.8%.更多还原

【Abstract】 Using sulpiride(SUL) as template,methacrylic acid(MAA) as function monomer,and ethyleneglycol dimethacrylate(EDMA) as cross linker,a molecularly imprinted polymer(MIP) was synthesized by bulk polymerization.Static adsorption and isothermal adsorption experiments were performed to study the influential factors on adsorption properties of the MIP to SUL by UV,FT-IR and SEM analysis.Adsorption mechanism of the MIP was also analyzed.The results showed that its best imprinting effect on SUL was observed when the volume of acetonitrile was 6 mL,molar ratio of SUL to MAA 1 to 4,and methanol-acetic acid(9:1,φ) used as eluting agent.The MIP offered uniform,loose and porous structure with 79.12 μmol/g of maximum adsorption capacity and 3.76 of imprinted factor for SUL.The main recognition sites of MIP were cavities caused by three types of amino groups on amide,benzsulfamide and 1-methylpyrrolidine in molecular structure.The MIP had better specific adsorption and exhibited good recognition and selectivity to SUL and its analogues such as amisulpride and tiapride.Their specific adsorption rates were respectively 68.35%,66.72% and 58.8%.Thus,the MIP could be used in separation and analysis for SUL drugs.更多还原