【摘要】 延龄草苷是中药中的一个有效成分,采用提取分离的方法从中药材大量获得它是困难的.我们以易得的原料薯蓣皂素和葡萄糖为原料合成了它.首先从葡萄糖起始,通过酰化、溴代反应,采用一锅煮的方法合成中间体溴-D-四乙酰葡萄糖;再与薯蓣皂素通过催化剂Hg(Ac)催化立体选择性的生成β-苷键,水解反应制备得到延龄草苷,总产率38.2%。反应条件温和,适于大量制备。产物结构通过IR,1HNMR和MS确证。更多还原

【Abstract】 Trillin is an effective components in traditional Chinese Medicine,It is difficult to get a large amount by using extraction method from Chinese herbal medicine.We studied a method to get it from diosgenin and Glucose to synthesiz it.Starting from glucose,via acylation,bromination reaction,using a one-pot method synthesis intermediates bromide –D-four acetyl glucose;Reracting with the Diosgenin by catalyst Hg(Ac)2 Catalyzed stereoselective format beta glycoside bond,then hydrolysis to preparre Trillin,total yield of 38.2%.The preparation are mild and it are suitable for scal-up.The structure of trillin was confirmed by IR,1HNMR and MS.更多还原