【摘要】 目的观察疏血通注射液股动脉加压灌注对Ⅱ期下肢动脉硬化闭塞症的影响。方法将120例Ⅱ期下肢动脉硬化闭塞症患者随机分为2组,治疗组60例采用疏血通注射液股动脉加压灌注治疗,对照组60例采用疏血通注射液静脉滴注治疗。2组均20 d为1个疗程,共治疗1个疗程。观察2组治疗前后血液流变学指标及纤维蛋白原定量变化情况,检测患肢治疗前后血流束宽度及血流频谱峰值,统计临床疗效,评价安全性。结果治疗组总有效率95.0%,对照组总有效率83.3%,2组总有效率比较差异有统计学意义(P<0.05),治疗组疗效优于对照组。2组治疗后血液流变学指标、纤维蛋白原定量、血流束宽度及血流频谱峰值与本组治疗前比较均明显改善(P<0.05,P<0.01),且治疗组全血黏度(低切)及血浆黏度,股浅动脉、足背动脉、胫后动脉的血流束宽度及股浅动脉、腘动脉、胫前动脉的血流频谱峰值改善均优于对照组(P<0.05)。2组均无明显不良反应。结论采用股动脉加压灌注疏血通注射液治疗Ⅱ期下肢动脉硬化闭塞症安全、有效,值得临床推广应用。更多还原

【Abstract】 Objective To the effect of femoral artery pressure perfusion of Shuxuetong injection on the treatment of phase Ⅱ lower limb arteriosclerosis obliterans.Methods 120 patients with phase Ⅱ lower limb arteriosclerosis obliterans were randomly divided into two groups.60 cases in treatment group were treated by femoral artery pressure perfusion of Shuxuetong injection.60 cases in control group were treated by intravenous infusion of Shuxuetong injection.The therapeutic course was 20 days in two groups.The changes of hemorheology index and fibrinogen before and after treatment were observed in the two groups.Flow beam width and peak flow spectrum before and after treatment were detected.Results The total effective rate in treatment group(95.0%) was superior to that in control group(83.3%,P<0.05).Hemorheology,fibrin quantitative,blood flow beam width and flow spectrum peak after treatment were significantly improved as compared with those before treatment in two groups(P<0.05,P<0.01).The improvement of whole blood viscosity(low shear) and plasma viscosity,blood flow beam width of superficial femoral artery,dorsalis pedis artery and flow spectrum peak of the posterior tibial artery and the superficial femoral artery,popliteal artery and anterior tibial artery in treatment group were superior to those in control group(P<0.05).There was no obvious adverse reaction in two groups.Conclusion Femoral artery pressure perfusion of Shuxuetong injection for the treatment of phase Ⅱ lower limb arteriosclerosis obliterans was safe,effective and worthy of clinical application.更多还原