【摘要】 目的检测肝癌(HCC)患者组织中IGF-Ⅱ、血管内皮生长因子(VEGF)的表达及临床意义。方法采用免疫组织化学染色方法检测HCC及癌旁组织中IGF-Ⅱ、VEGF蛋白表达水平。结果 HCC及癌旁组织IGF-Ⅱ蛋白阳性表达率分别为55%(22/40)、12.5%(5/40),VEGF蛋白阳性表达率分别为62.5%(25/40)、12.5%(5/40),HCC组织中IGF-Ⅱ、VEGF蛋白表达均显著高于癌旁组织(P<0.05),且IGF-Ⅱ、VEGF表达呈明显正相关(r=0.59,P<0.05)。IGF-Ⅱ、VEGF表达与患者的年龄、性别、肿瘤大小无关,但与肿瘤的组织学分级、是否侵及包膜及有无癌栓密切相关。结论与癌旁组织比较,HCC组织中IGF-Ⅱ、VEGF呈现高表达,提示IGF-Ⅱ、VEGF参与了HCC的发生发展过程,可能与HCC的生长和增殖有关。更多还原

【Abstract】 Objective To investigate the expression and significance of IGF-Ⅱand VEGF in tissues of hepatocellular carcinoma(HCC).Methods The expression of IGF-Ⅱand VEGF in HCC tissues were detected by means of immunohistochemistry.Results The expression rates of IGF-Ⅱ in HCC and tumor-adjacent tissues were 55%(22/40),12.5%(5/40),respevtively,and the expression rates of VEGF were 62.5%(25/40),12.5%(5/40),respectively.The expression rates of IGF-Ⅱ and VEGF were significantly higher than those in tumor-adjacent tissues(P<0.05),furthermore,the expression of IGF-Ⅱ was positively correlated with that of VEGF(r=0.59,P<0.05).The expression of IGF-Ⅱand VEGF protein was not related with patients’ sex,age or tumor’s size,however,which was closely correlated with histological grade,capsule violation and cancer embolus of tumors(P<0.05).Conclusion The overexpression of IGF-Ⅱand VEGF in HCC tissues may participate in the pathogenesis and progression of HCC,which may be correlated with the growth and proliferation of HCC.更多还原