【摘要】 目的探讨胰岛素样生长因子-Ⅰ(insulin-like growth factor-Ⅰ,IGF-Ⅰ)、胰岛素样生长因子-Ⅱ(insulin-like growth factor-Ⅱ,IGF-Ⅱ)在胃癌中的表达及与胃癌浸润转移等生物学行为的关系。方法对胃癌患者40例的癌组织、距原发灶5cm以上切缘组织和正常胃组织标本10例进行IGF-Ⅰ、IGF-Ⅱ免疫组织化学染色。结果①胃癌组织中IGF-Ⅰ的表达率显著高于切缘组织和对照组(P<0.05);切缘组织和对照组中表达率差异无统计学意义(P>0.05);病理分期中Ⅰ、Ⅱ期与Ⅲ、Ⅳ期比较差异有统计学意义(P<0.05);无淋巴结转移组与淋巴结转移组相比差异有统计学意义(P<0.05);未侵及全层组与侵及全层组相比差异有统计学意义(P<0.05)。②胃癌组织中IGF-Ⅱ的表达率显著高于切缘组织和对照组(P<0.05)。切缘组织和对照组中表达率差异无统计学意义(P>0.05)。病理分期中Ⅰ、Ⅱ期与Ⅲ、Ⅳ期比较差异有统计学意义(P<0.05);无淋巴结转移组与淋巴结转移组相比差异有统计学意义(P<0.05);未侵及全层组与侵及全层组相比差异有统计学意义(P<0.05)。结论 IGF-Ⅰ、IGF-Ⅱ的高表达与胃癌的发生有关,且均参与了胃癌的侵袭和转移。更多还原

【Abstract】 Objective To investigate the relationship of the expression of insulin - like growth factor -Ⅰ(IGF -Ⅰ) and insulin - like growth factor -Ⅱ(IGF -Ⅱ) with the histological type, pathologic tumor - node - metastasis(PTNM) stage,infiltration as well as metastasis of gastric carcinoma (GC ).Methods The expression of IGF -Ⅰand IGF -Ⅱwere tested by S - P immunohistochemistry in 40 cases of GC tissues,margin tissues which were more than 5 cm from primary focus in distance and 10 cases of normal gastric mucosa.Results①The expression rate of IGF -Ⅰin GC group was much higher than in margin tissues and normal gastric mucosa groups(P < 0.05 ).There was no significant difference between margin tissues group and normal gastric mucosa groups(P >0.05).The expression of IGF -Ⅰwas closely correlated to the tumor PTNM stage,lymph node metastasis and depth of infiltration (P <0.05).②The expression rate of IGF -Ⅱin GC group was much higher than in margin tissues and normal gastric mucosa groups(P < 0.05).There was no significant difference between margin tissues group and normal gastric mucosa group(P > 0.05 ).The expression of IGF -Ⅱwas closely correlated to the tumor PTNM stage,lymph node metastasis and depth of infiltration(P < 0.05).Conclusion The excessive expression of IGF -Ⅰand IGF -Ⅱis closely correlated to carcinogenesis of GC.It may be involved in the development,infiltration and metastasis of GC.更多还原