【摘要】 类鼻疽伯克霍尔德菌(Burkholderia pseudomallei)是引起主要发生在东南亚和澳大利亚北部的一种人兽共患病类鼻疽的潜在病原。明确该疾病致病机理及其宿主与病原的互作将加强对该条件致病菌的发病机制的理解。本研究从影响细菌致病性的毒力因子和病原与宿主互作两个方面阐述类鼻疽伯克霍德尔菌的致病机理,为该菌的有效控制提供可能的机制。更多还原

【Abstract】 Burkholderia pseudomallei is a potential bioterror agent and the causative agent of melioidosis,a severe disease that is endemic in areas of Southeast Asia and Northern Australia. Studying how the disease is acquired and the host-pathogen interactions involved will underpin understanding of the bacteria. This review presents an overview focused on current knowledge of putative virulence factors and the host-pathogen interactions,led to understanding of the infection process of Burkholderia pseudomallei and effective control strategy.更多还原