【摘要】 目的观察白花丹醌对白血病异种移植瘤的体内作用。方法用NB4细胞构建白血病小鼠模型,白花丹醌组(2mg/(kg.d)),亚砷酸组(4mg/(kg.d)),分别腹腔给药15d,计算抑瘤率,凋亡指数(AI)并进行病理组织学检查。结果白花丹醌组抑瘤率为40.49%(P<0.01),AI为(8.52±1.49)%(P<0.01),未出现明显的病理组织损伤。亚砷酸组则无明显的抑瘤作用,凋亡作用不明显(P>0.05),部分伴有心肌组织的损伤。结论 :白花丹醌具有抑制肿瘤生长,诱导凋亡的作用,可能成为白血病治疗的新选择。更多还原

【Abstract】 OBJECTIVE To observe the effect of Plumbagin in vivo using xenografts mice.METHODS The leukemia mouse model was developed with implantation of NB4 cell;plumbagin group(2mg/(kg·d)) and arsenic trioxide group(4mg/(kg·d)) were treated for 15 days by i.p route;suppression of tumor growth and the apoptotic index(AI) were calculated.The histopathologic change was detected.RESUTLS The inhibition rates of plumbagin group was 40.49%(P<0.01),AI was(8.52±1.49)%(P<0.01),and without any obvious pathology of tissue damage.There was no significant effect in arsenic trioxide group except some tissue damage in heart.CONCLUSION Plumbagin may inhibit tumour growth and induce apoptosis,can be a new choice for leubemia treatment.更多还原