【摘要】 目的观察氟比洛芬酯对微创经皮肾镜手术(mPCNL)后疼痛治疗效果的影响。方法将40例ASAⅠ～Ⅱ级成人择期行微创经皮肾镜手术患者,随机分成K组和N组,每组20例。K组于麻醉后、手术开始前10min静脉注射氟比洛芬酯1mg/kg,N组于麻醉后静脉注射生理盐水。术前(入室时,T0)、术后2h(T1)、4h(T2)、12h(T3)、24h(T4)采用VAS法进行疼痛评分并记录不良反应。结果手术后K组与N组VAS评分差异有统计学意义(P<0.05),K组各观察时点的VAS评分均低于N组,但是两组术后患者生命体征基本平稳,两组之间差异无统计学意义(P>0.05)。结论在微创皮肾镜手术(mPCNL)术前,单次用氟比洛芬酯1mg/kg于围手术期镇痛具有确切疗效,并且操作方法简单和具有安全性。更多还原

【Abstract】 Objective To observe the effect of flurbiprofen axetil on preemptive analgesia after minimally percutaneous nephrolithotomy(mPCNL).Methods Forty ASAⅠⅡadult patients of ASAⅠ~Ⅱ undergone scheduled for mPCNL were randomly divided into group K and group N,each had with 20 cases.Each pPatient in group K in anesthesia,10 minutes before the surgery was received intravenous injectiona blous of 1 mg ·/kg-1 flurbiprofen axetil in anesthesia,10 minutes before surgery,while those in Group N was were administered with saline intravenously after anesthesia.Pain was scored by visual analogue scale(VAS) and the adverse reactions were recorded Preoperative preoperative(The home invasion,T0),2 h after 2 h(T1),4 h(T2),12 h(T3),24 h(T4) after surgery,method using the Visual analogue scale(VAS) pain score and record adverse reactions.Results There were a statistically significant difference of the VAS scores between the two groups(P<0.05).The VAS scores in group K at each time points were lower than those in group N,but there were no statistically significant differences in patients’ vital signs between two groups(P>0.05).Conclusion Before mPCNL,single use of flurbiprofen axetil is effective for preemptive analgesia,characterized by simple operationhas and good safety.更多还原