【摘要】 为了观察HIV-1阳性病人血清IL-18和IL-18BP水平与疾病的关系,用ELISA法检测67例经HAART治疗的HIV-1阳性病人及18例正常对照者血清的IL-18和IL-18BP水平。结果显示,HIV-1感染组血清IL-18水平明显高于正常对照组(P<0.01),其中A类HIV-1感染组IL-18水平高于正常对照组(P<0.05),B类、C类HIV-1感染组IL-18水平明显高于正常对照组(P<0.01);HIV-1感染组血清IL-18BP的水平明显高于正常人(P<0.01),其中各类HIV-1感染组IL-18BP水平均高于正常对照组(P<0.05);正常对照组IL-18和IL-18BP水平呈正相关(r=0.705,P<0.01),HIV-1感染组的IL-18和IL-18BP水平无相关性。可见,IL-18和IL-18BP水平的变化及失衡与艾滋病的发生、发展相关,动态监测外周血IL-18及IL-18BP水平可作为反映HIV-1感染者的免疫功能状态变化指标,调节体内IL-18、IL-18BP水平的平衡可能为艾滋病治疗提供新途径。更多还原

【Abstract】 To investigate the clinical significance and changes of IL-18and IL-18BP in serum in HIV-infected patients,the levels of IL-18 and IL-18BP in serum were detected by ELISA in 67 cases of HIV-1 infestors with HAART and 18 cases of healthy persons.The levels of IL-18 in serum of HIV-1 group were significantly higher than those of control group(P<0.01),the levels of IL-18 in serum of HIV-1 group A were higher than those of control group(P<0.05);The levels of IL-18 in serum of HIV-1 group B and HIV-1 group C were significantly higher than those of control group(P<0.01);The levels of IL-18BP in serum of HIV-1 group were significantly higher than those of control group(P<0.01),the levels of IL-18 in serum of three HIV-1 groups were higher than those of control group(P<0.05);A significant positive correlation was found between the levels of IL-18 and IL-18BP in healthy persons(r=0.705,P<0.01).The levels of IL-18 had no correlation with the levels of IL-18BP in serum of three HIV-1 groups.Increased levels of IL-18 and IL-18BP may play important roles in the occurrence and progression of AIDS,and the imbalance between IL-18 and IL-18BP may participate in it too.Dynamic monitoring of IL-18 and IL-18 BP in peripheral blood can be used as a reflection of the immune function of state changes index in HIV-1 infected patients.Regulating the balance between IL-18 and IL-18 BP may provide a new approach for the treatment of AIDS.更多还原