【摘要】 目的研究骨髓增生异常综合征(MDS)和再生障碍性贫血(AA)患者外周血中性粒细胞和淋巴细胞VCS参数的改变及其诊断价值。方法通过LH750血液分析仪(Beckman Coulter)进行血常规检测,分析85例存在全血细胞减少的患者中性粒细胞和淋巴细胞VCS参数。其中MDS 45例,AA 40例,并以120例健康体检者为对照组。结果与对照组相比,AA患者中性粒细胞平均体积(MNV)和淋巴细胞平均散射率(MLS)增高,而MDS患者MNV、中性粒细胞平均电导率(MNC)、淋巴细胞平均体积(MLV)、淋巴细胞平均电导率(MLC)和MLS均增高,中性粒细胞平均散射率(MNS)降低,差异具有统计学意义(P<0.01)。MDS和AA患者的MNS、MLV和MLC比较差异有统计学意义(P<0.01)。结论外周血中性粒细胞和淋巴细胞VCS参数对MDS和AA患者的诊断及鉴别诊断具有一定价值。更多还原

【Abstract】 Objective To study changes in neutrophil and lymphocyte VCS parameter in patients with MDS and AA.Methods Neutrophil and lymphocyte VCS parameters:V(volume),C(conductivity) and S(light scattering) were studied in a group of 120 healthy subjects 45 cases of myelodysplastic syndrome(MDS) and 40 cases of aplastic anemia(AA),by using a LH-750 hematology analyzer(Beckman Coulter).Results The mean neutrophil volume(MNV) and mean lymphocyte scatter(MLS) of AA were significantly higher in comparison to control group(P<0.01).The mean neutrophil volume,conductivity(MNC) and mean lymphocyte volume(MLV),conductivity(MLC) and scatter(MLS) of MDS increased(P<0.01),whereas mean neutrophil scatter(MNS) decreased(P<0.01).The MNS,MLV and MLC of MDS were significant different in comparison to AA.Conclusion The neutrophil and lymphocyte VCS parameters may be useful for diagnosis and differentiated diagnosis in MDS and AA.更多还原