【摘要】 目的探讨诱骗受体3(DcR3)与γ-干扰素/白细胞介素-4(IFN-γ/IL-4)分泌模式在系统性红斑狼疮(SLE)患者免疫紊乱过程中发生的变化及两者的关系。方法采用ELISA双抗体夹心法检测36例SLE患者和32例健康者血清中DcR3、IL-4和IFN-γ的水平。结果 SLE患者血清DcR3、IFN-γ和IL-4水平显著升高(P<0.01);DcR3与IL-4呈正相关(r=0.340,P<0.05),与IFN-γ无明显相关关系(r=-0.105,P>0.05),与IFN-γ/IL-4呈负相关(r=-0.332,P<0.05)。结论 SLE患者血清DcR3水平显著升高,可能参与SLE的发生发展过程;SLE患者Th1/Th2细胞因子分泌模式复杂,不同患者可能分别表现为Th1细胞或Th2细胞优势;SLE中DcR3具有一定的促Th2偏移作用。更多还原

【Abstract】 Objective To investigate the level of decoy receptor 3(DcR3)and the characteristics of IFN-γ/IL-4pattern in patients with systemic lupus erythematosus(SLE).Methods 36patients with SLE and 32healthy volunteers as controls were included in the study.Serum levels of DcR3,IL-4and IFN-γwere determined by double-antibody-sandwich enzyme linked immunosorbent assay(ELISA).Results Compared with the healthy volunteers,significantly higher serum DcR3,IFN-γand IL-4concentrations were detected in SLE patients(P<0.01).DcR3correlated positively with IL-4(r=0.340,P<0.05)and negatively with IFN-γ/IL4ratio(r=-0.332,P<0.05),while no correlation was observed between DcR3and IFN-γ(r=-0.105,P>0.05).Conclusion DcR3might be involved in the development of SLE.Th1/Th2cytokines pattern might be complex in SLE and different in individual SLE patients.DcR3might promote T helper cells transforming into Th2cells to some extent in SLE patients.更多还原