【摘要】 目的探讨各生物学标志物对急性脑梗死预后的影响。方法选取急性脑梗死病例111例,健康对照组104例,在发病24h内、发病后3d检测病例组血清S100B蛋白、髓鞘碱性蛋白(MBP)、胶质纤维酸性蛋白(GFAP)、白细胞介素-6(IL-6)浓度,在发病24h内检测血清超敏C-反应蛋白(hs-CRP)、血浆D-二聚体(DD)浓度,并于体检当天检测对照组相应标志物浓度。对各标志物浓度及风险因素进行Logistic回归分析。结果血清IL-6、S100B、吸烟、GFAP、hs-CRP、MBP、血浆DD、体质量指数、饮酒与急性脑梗死的不良结局相关,其OR值分别为3.21、2.70、2.53、2.11、1.91、1.57、1.50、1.13、1.11。结论血清IL-6、S100B、吸烟、GFAP、hs-CRP、MBP、血浆DD、体质量指数、饮酒与急性脑梗死的不良结局相关,监测其变化对急性脑梗死的预后评估有重要意义。更多还原

【Abstract】 Objective To evaluate the prognosis effects of biological markers on acute cerebral infarction.Methods 111patients with acute cerebral infarction and 104normal controls were randomly recruited.S100Bprotein,myelin basic protein(MBP),glial fibrillary acidic protein(GFAP),interleukin-6(IL-6)were determined within 24hand 3dafter acute cerebral infarction.All biological markers’concentration in normal controls were determined immediately after medical check-up.All biological markers and risk factors were evaluated by logistic regression.Results The logistic regression analysis results showed that serum IL-6,S100Bprotein,smoking,GFAP,hs-CRP,MBP,D-Dimer,body mass index,alcohol drunken were associated with poor outcomes of acute cerebral infarction,odds ratio(OR)values were 3.21,2.70,2.53,2.11,1.91,1.57,1.50,1.13and 1.11.Conclusion IL-6,S100Bprotein,smoking,glial fibrillary acidic protein,hs-CRP,myelin basic protein,D-Dimer,body mass index,alcohol drunken were associated with poor outcomes of acute cerebral infarction.It has great significance to monitor the changing of those markers for prognosis evaluation of acute cerebral infarction.更多还原