【摘要】 目的分析宝鸡地区孕妇产前筛查中染色体疾病的发病率。方法对1 478例孕98～146d孕妇进行血清甲胎蛋白和游离β人绒毛膜促性腺激素检测,结合孕妇的体质量、年龄、孕期等因素利用软件进行风险评估。结果 21-三体综合征、18-三体综合征和神经管缺陷高风险阳性率分别为3.4%(50/1 478)、0.9%(14/1 478)和0.9%(14/1 478)。结论孕中期产前筛查是预防染色体疾病患儿出生的重要途径,对避免出生缺陷、提高出生人口素质具有重要意义。更多还原

【Abstract】 Objective To analyze the incidence of chromosomal diseases in the prenatal screening among pregnant women in Baoji.Methods 1 478 cases of pregnant women at pregnancy period of 98-146 day was detected for serum levels of alpha-fetoprotein and free beta human chorionic gonadotropin,results of which were combined with pregnant woman′s body weight,age,pregnancy cycle and other factors to perform risk evaluation by using software analysis.Results The high-risk positive rates of 21-Trisomy syndrome,18-Trisomy syndrome and neural tube defects were 3.4%(50/1 478),0.9%(14/1 478) and 0.9%(14/1 478) respectively.Conclusion Prenatal screening at intermediate stage of pregnancy might be an important method for preventing the birth of children with chromosomal diseases,with significant value for avoiding birth defect and improving population quality.更多还原