【摘要】 目的研究建立ESR-30型全自动动态血沉仪的参考区间。方法将仪器法与魏氏法进行比对评价,然后对800例健康体检者按性别、年龄分组。对差异无统计学意义的组合并,符合正态分布时用x±1.96s确定参考区间,不符合正态性分布用95%百分位数法确定参考区间。结果经比对评价,仪器法与魏氏法结果差异无统计学意义(t=1.618,P=0.122)。健康人群红细胞沉降率(ESR)的频数分布不符合正态性,性别间结果差异有统计学意义(Z=-2.956,P=0.003)。ESR有随年龄增加而加快的趋势,最终确定的参考区间为,男(≤60岁)0～23.0mm/h;男(>60岁)0～37.0mm/h,女0～37.0mm/h。结论仪器法与魏氏法结果可比性良好,适合临床实验室应用,健康人群的ESR参考区间与以往文献所载有较大差别,应引起检验人员与临床医师的关注。更多还原

【Abstract】 Objective To investigate and establish the reference range of full auto-dynamic erythrocyte sedimentation rate(ESR) instrument.Methods Instrument and Westergren method were contrasted and evaluated.Vein blood samples were collected from 800 healthy physical examination individuals before breakfast,and anti-coagulated by 109 mmol/L trisodium citrate.All individuals were grouped by sex and age.Significant test was performed between different groups.Frequency distribution was confirmed by normal condition test.The results with no statistical meaning for difference were combined.The reference value was ascertained by x±1.96s for data with normal condition distribution and 95% percent digit for data without normal condition distribution.Results Through contrasting and evaluating,there was no statistical meaning difference between the results of instrument and Westergren method(n=20,t=1.618,P=0.122).The frequency distribution of healthy people′s ESR was not condition distribution.There were statistical meaning differences between the results of men and women(Z=-2.956,P=0.003).There was hoist trend by age.There were statistical meaning to results in groups older than 61 and younger than 60 for men(Z=-4.574,P=0.000).There was no statistical meaning difference between the results in over-60s and aged 60 or below for women(Z=-1.322,P=0.185).The reference ranges according to the method were 0-23.0 mm/h for men aged 60 or below,0-37.0 mm/h for men aged more than 60,and 0-37.0 mm/h for women,respectively.Conclusion The result comparability of instrument method and Westergren method is good.Instrument method is suitable for clinical laboratory application.ESR reference ranges of healthy people are quite different from those reported in previous literatures,which should be taken care of.更多还原