【摘要】 目的探讨珠蛋白生成障碍性贫血基因携带者的血清铁、血清铁蛋白的浓度,了解铁负荷的状况,为预防高铁负荷危害提供理论依据。方法将珠蛋白生成障碍性贫血基因携带者109例,健康者151例,分别设为病例组和对照组。使用美国Beckman LH750全自动血细胞仪测定RBC、Hb、MCV、RDW,美国Beckman SynchronLX-20全自动生化仪测定血清铁,德国Roche6000全自动电化学发光测定血清铁蛋白。结果病例组的珠蛋白生成障碍性贫血基因携带者的血清铁和血清铁蛋白和对照组的数据经统计学比较,差异有统计学意义(P<0.05)。结论珠蛋白生成障碍性贫血基因携带者体内血清铁、血清铁蛋白明显高于对照组,存在高铁负荷的状态,应加强监测铁负荷,预防高铁引起的各类并发症。更多还原

【Abstract】 Objective To investigate serum levels of iron and ferritin in thalassemic trait adults.Methods 260 cases of thalassemic trait adults(case group) and 151 cases of healthy subjects(control group) were enrolled and detected for RBC,Hb,MCV,RDW by using Beckman LH750 system,for serum iron by using Beckman Synchron LX-20 system and for serum ferritin by using Roche6000 system.Results There were statistical differences in serum levels of iron and ferritin between case group and control group(P<0.05).Conclusion Serum levels of iron and ferritin in thalassemic trait adults might be higher than those in healthy subjects,indicating that there might be overloaded iron in thalassemic trait adults and monitoring of iron loading should be strengthened to prevent diseases caused by iron overloading.更多还原