【摘要】 目的探讨尿肾损伤因子-1(KIM-1)、尿微量清蛋白(mALB)、β2微球蛋白(β2-MG)联合检测对2型糖尿病(T2DM)早期肾损伤的诊断价值。方法 81例T2DM患者分为糖尿病肾病(DN)组38例,不伴DN组43例,以45例健康体检者为健康对照组。尿KIM-1用酶联免疫吸附法(ELISA)测定,尿mALB和β2-MG用全自动生化分析仪测定。结果 T2DM患者尿KIM-1、mALB、β2-MG水平明显高于健康对照组(P<0.01);T2DM患者DN组尿KIM-1、mALB、β2-MG水平明显高于不伴DN组(P<0.05);联合检测阳性率达93.8%,明显高于单项检测。结论联合检测尿KIM-1、mALB和β2-MG对T2DM早期肾损伤的诊断更为敏感。更多还原

【Abstract】 Objective To explore the value of associated detection of urine kidney injury molecule-1(KIM-1),urinary microalbumin(mALB) and β2-microglobulin(β2-MG) for the diagnosis of early diabetic nephropathy.Methods 81 patients with type 2 diabetes mellitus(T2DM) were divided into DM group(43 cases) without diabetic nephropathy(DN) and DN group(38 cases).Healthy subjects(45 cases) were enrolled as control group.Urine KIM-1 was detected by ELISA,and mALB and β2-MG were examined by automatic biochemical analyzer.Results In all patients with T2DM,urine levels of KIM-1,mALB and β2-MG were significantly higher than those in control group(P<0.01),and in DN group were significantly higher than in DM group(P<0.05).The positive rate of combined detection of KIM-1,mALB and β2-MG was 93.8%,significantly higher than that of single test.Conclusion Urine KIM-1,mALB and β2-MG might be sensitive indicators of early diabetic renal injury,and combined detection could be more sensitive.更多还原