【摘要】 目的探讨血浆肾素(PRA)、血管紧张素Ⅱ(AngⅡ)以及醛固酮(Ald)的水平与妊娠期先兆子痫的关系。方法选择妊娠期先兆子痫患者27例作为病例组,随机选取同期健康妊娠妇女51例、健康未妊娠妇女35例作为对照组,检测其血浆PRA、AngⅡ及Ald水平,并对各指标进行组间比较。结果与健康妊娠妇女相比,先兆子痫患者的AngⅡ水平明显升高,而PRA、Ald水平明显下降,差异均有统计学意义(P<0.05);与健康未妊娠妇女相比,先兆子痫患者的AngⅡ水平也明显升高(P<0.05)。结论先兆子痫患者的血浆PRA、AngⅡ、Ald水平发生变化,可能与它们参与先兆子痫的病理生理过程有关。更多还原

【Abstract】 Objective To investigate the relationship between the plasma levels of renin(PRA),angiotensin Ⅱ(Ang Ⅱ) and aldosterone(Ald) and preeclampsia during pregnancy.Methods 27preeclampsia patients(case group),51healthy pregnant women and 35healthy non-pregnant women were randomly selected as control groups.Plasma levels of PRA,Ang Ⅱ and Ald were detected and compared between different groups.Results The plasma Ang Ⅱ level was significantly higher in case group than that in healthy pregnant women,while the plasma PRA and Ald levels were significantly lower(P<0.05).The plasma Ang Ⅱ level in case group was also significantly higher than that in healthy non-pregnant women(P<0.05).Conclusion The changing plasma levels of PRA,Ang Ⅱ and Ald in preeclampsia patients might be related to their involvements in the pathophysiology of preeclampsia.更多还原