【摘要】 目的探讨女性妊娠中期唐氏筛查对宫内诊断的临床价值以及对不同年龄段的异常率差异分析。方法采用磁微粒化学发光法对14 742例妊娠中期女性进行血清甲胎蛋白(AFP)、游离β-人绒毛膜促性腺激素(f-β-HCG)和游离雌三醇(uE3)检测,并计算风险值。结果 621例孕妇筛查结果为高风险,阳性率为4.21%,检出NTD高风险孕妇378例,筛查阳性率为1.40%,检出爱德华综合征(Es)高风险孕妇36例,筛查阳性率为0.24%(36/14 742),在不同年龄的高风险分组中,大于或等于35岁组与其他组别作统计比较,唐氏综合征(Ds)风险率差异有统计学意义(P<0.05),各年龄组胎儿神经管缺陷(NTDs)风险率差异无统计学意义(P>0.05)。结论产前筛查对于宫内诊断具有重要的临床价值,高风险对产前诊断起重要的指导作用。更多还原

【Abstract】 Objective To explore the clinical value of Down′s syndrome screening in the intrauterine diagnosis and analyze the difference of abnormal rate between different age group.Methods Serum alpha-fetoprotein(AFP),unconjugated estriol(uE3) and free-β-human chorionic gonadotrophin(f-β-HCG) level of 14 742 women in the second trimester were detected by magnetic particle chemiluminescence and the risk value was calculated.Results 621 cases were with high risk,and the positive rate was 4.21%.378 cases were with neural tube defects(NTD),the detectable rate was 1.40%.In different age groups of high-risk,there were statistical difference of risk rate of Down′s syndrome between equal with or more than 35 year-old group and other groups(P<0.05),but there was no statistical difference of risk rate of NTD between different groups(P>0.05).Conclusion Prenatal screening might be with important clinical value for intrauterine diagnosis,and high-risk could be important to guide prenatal diagnosis.更多还原