【摘要】 目的:观察参附注射液对慢性充血性心力衰竭(CHF)患者血清B型脑利钠肽(BNP)、肿瘤坏死因子-α(TNF-α)、白介素6(IL-6)及C反应蛋白(CRP)水平的影响。方法:将160例符合纳入标准的CHF患者随机分为观察组、对照组各80例。2组均给予常规治疗,观察组同时给予参附注射液。2组均于治疗前、后抽取静脉血测定血清中BNP、CRP、TNF-α、IL-6含量。结果:2组心功能Ⅱ级、Ⅳ级、Ⅲ级患者BNP、TNF-α、IL-6、CRP水平治疗后均明显改善,治疗前后组内相比差异显著(P<0.05),治疗后组间相比差异显著(P<0.05)。结论:参附注射液可改善慢性充血性心力衰竭患者血清BNP、CRP、TNF-α、IL-6水平,心功能越差效果越明显。更多还原

【Abstract】 Objective: To observe effect of ShenFu injection on levels of BNP,CRP,TNF-α and IL-6 in serum of patients with chronic congestive heart failure(CHF).Method: A total of 160 cases were assigned into observation group and control group randomly.Both groups received symptomatic treatment.Observation group were administered with ShenFu injection.once each day.Contents of BNP,CRP,TNF-α and IL-6 in serum were detected before and after treating.Result: Levels of BNP,CRP,TNF-α and IL-6 in serum of patients of cardiac function class Ⅱ,Ⅳ and Ⅲ improved remarkably after treating,comparison within one group showed notable difference before and after treating(P<0.05),comparison after treating between both groups suggested significant difference(P<0.05).Conclusion: ShenFu injection can improve levels of serum BNP,CRP,TNF-α and IL-6 of patients with CHF,the worst cardiac function was,the more evident curative effects was.更多还原