【摘要】 目的:通过兰州市4家医院协作,包括甘肃省肿瘤医院、兰州大学第二医院、兰州大学第一医院、甘肃省人民医院,对初次住院治疗,并经病理确诊的淋巴瘤患者病理类型进行分析,总结其特点。方法:收集2009年1月2日至2011年6月30日,在兰州市4家医院初次住院治疗的淋巴瘤患者,均进行了病理和免疫组化的确诊,包括淋巴结、淋巴组织器官或骨髓等,对其性别、年龄、病理类型进行分析。结果:330例患者,男189例,女141例,男女之比为1.3∶1;年龄分布,41~70岁是个发病高峰。根据2008年WHO淋巴系统恶性肿瘤分类,330例恶性淋巴瘤患者中,霍奇金淋巴瘤54例,占16.4%;非霍奇金淋巴瘤276例,占83.6%,其中B细胞肿瘤201例,占72.8%;T细胞肿瘤75例,占27.2%。201例B细胞肿瘤中,最常见的是弥漫大B细胞淋巴瘤120例,占59.7%;其次是慢性淋巴细胞白血病/小淋巴细胞淋巴瘤25例,占12.4%;结外粘膜相关淋巴组织边缘区B细胞淋巴瘤20例,占10.0%;滤泡淋巴瘤11例,占5.4%;其他类型均≤4%。75例T细胞肿瘤中,最常见的是结外NK/T细胞淋巴瘤,鼻型26例,占34.7%;其次是外周T细胞淋巴瘤,非特异型16例,占21.3%;前体T淋巴母细胞淋巴瘤/白血病16例,占21.3%;其他类型均≤5%。霍奇金淋巴瘤54例中,结节性淋巴细胞为主淋巴瘤2例,占3.7%;结节硬化型霍奇金淋巴瘤13例,占24.0%;混合细胞型霍奇金淋巴瘤15例,占27.8%;富于淋巴细胞的经典型霍奇金淋巴瘤23例,占42.6%;淋巴细胞消减型1例,占1.9%。结论:兰州地区的恶性淋巴瘤在其性别、年龄、病理类型方面有其特点。更多还原

【Abstract】 Objective:To analyze the feature of distribution pattern of malignant lymphoma pathological subtypes in a multicenter study in initial hospitalization inpatients by 4 hospitals in Lanzhou, including Gansu tumor hospital,the second hospital of Lanzhou university,the first hospital of Lanzhou university and the people’s hospital of Gansu province. Methods: Malignant lymphoma cases with pathological diagnosis in initial hospitalization inpatients by 4 hospitals in Lanzhou,from Jan 2009 to June 2010,were collected in which their sex,age and pathological subtypes were analysed. Results: 330 patients comprised 189 males and 141 females(with a male to female ratio of 1.3∶1),with a high disease age of 41~70 years,according to the new WHO(2008) classification,there were 54 cases(16.4%) of Hodgkin’s lymphoma(HL) and 276 cases(83.6%) of non-Hodgkin’s lymphoma(NHL).In the 276 NHL cases,B-cell neoplasms accounted for 201 cases(63.9%)and T/NK-cell neoplasms accounted for 75 cases(27.2%).In 201 B-cell neoplasms cases,the most common were diffuse large B-cell lymphoma(120 cases,59.7%),chronic lymphocytic leukemia/small lymphocytic lymphoma(25 cases,12.4%),extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (20 cases,10.0%),follicular lymphoma (11 cases,5.4%), and other classification lymphoma were≤4%. In 75T/NK-cell neoplasms cases,the most common were extranodal NK/T cell lymphoma of nasal type(26 cases,34.7%),unspecified peripheral T-cell lymphoma(16 cases,21.3%),T-lymphoblastic leukemia/lymphoma(16 cases,21.3%),and other classification lymphoma were ≤5%. In 54 Hodgkin lymphoma cases,nodular lymphocyte predominant Hodgkin lymphoma was 2 cases(3.7%),nodular sclerosis classical Hodgkin lymphoma was 13 cases(24.0%), mixed cellularity classical Hodgkin lymphoma was 15 cases(27.8%),lymphocyte-rich classical Hodgkin lymphoma was 23 cases(43.6%),lymphocyte-depleted classical Hodgkin lymphoma was 1 case(1.9%). Conclusion: There is a characteristic distribution pattern of malignant lymphoma in sex,age and subtypes in Lanzhou.更多还原