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层状纳米羟基磷灰石/茶氨酸药物释药性能研究
Drug Release Property of Layered Nano-hydroxyapatite/L-theanine
【摘要】 本文以层状纳米羟基磷灰石为载体制备了羟基磷灰石/茶氨酸药物,并对其体外释药性能进行了初步研究。羟基磷灰石/茶氨酸药物在起始阶段具有很快的药物释放速率,50 min时的累积释放量接近80%,最终的释药量可达90%以上。而且在释药初期,载药量高的样品比载药量低的样品具有更高的累积释药百分量。
【Abstract】 In this paper,layered nano-hydroxyapatite/theanine drug was prepared and the release property in vitro was investigated.The drug released with high speed at the beginning.The cumulative emission of L-theanine reached 80% after 50 min,and more than 90% in 2 h.Besides,the rate of hydroxyapatite loading more drug was relatively higher than loading less one.
【基金】 广东省重大科技专项(2010A080407008);中央高校基本科研业务费资助项目(2011ZM0015)
- 【文献出处】 硅酸盐通报 ,Bulletin of the Chinese Ceramic Society , 编辑部邮箱 ,2012年02期
- 【分类号】TQ460.1
- 【被引频次】2
- 【下载频次】177