【摘要】 根据人体胃肠环境变化特点,调节4个明矾炮制药材的水煎液的酸度,于37℃恒温水浴中保持1h之后,用0.45μm微孔滤膜、732氢型阳离子交换树脂分离水煎液中各种铝形态。湿法消解-石墨炉原子吸收光谱法(GFAAS)测定总铝量;GFAAS直接测定水煎液中各形态铝含量。得到了各样品中铝形态含量及分布情况,并且与未调节酸度的样品进行比较,讨论铝在胃肠的模拟系统影响下的形态转变原因。所得结果对明矾炮制药材中铝的安全性评价有参考价值。更多还原

【Abstract】 According to the characteristics of gastrointestinal environmental change,acidity of decoctions of four samples of alum processing Chinese medicine were adjusted.After the temperature of solution kept 37℃ for 1h in the constant temperature water bath,different aluminum species in the decoctions were obtained by two steps:filter through 0.45μm microfiltration membrane and then pass through the type 732 cation exchange resin column.Graphite furnace atomic absorption spectrometry(GFAAS) was used to determine total aluminum amount with wet digestion,and amount of aluminum species in the decoctions without digestion was directly determined by GFAAS.Amount of aluminum species and their distribution were given,which were compared with the decoctions whose acidity was not adjusted.The reasons about transformation of aluminum species in simulative gastrointestinal system were discussed.The results are valuable for evaluation of security of aluminum in alum processing Chinese medicines.更多还原