【摘要】 目的:通过对河源地区消化性溃疡穿孔(perforated peptic ulcer,PPU)状况的调查,了解PPU在本地区流行病学特点,为进一步预防和治疗PPU提供理论依据。方法:采用我院2007年1月至2010年12月急诊入院救治的540例PPU患者资料,回顾性分析其发生PPU的相关因素,包括PPU患者的性别、年龄、血型、吸烟、饮酒、溃疡病史及其治疗情况、H.pylori感染情况、服用非甾体类抗炎药(NSAIDs)以及季节因素。结果:十二指肠溃疡穿孔(perforated duodenal ulcer,PDU):胃溃疡穿孔(perforated gastric ulcer,PGU)为1.66∶1,不同血型构成比之间有显著差异(P<0.01),以O型血最多,吸烟对PPU有显著影响,>60岁的老年人比例最高,服用NSAIDs对PPU有显著影响,幽门螺杆菌感染率达80.74%,不同季节和PPU发病率有相关。结论:年龄、O型血、吸烟、服用NSAIDs和H.pylori感染是河源地区PPU发病的危险因素,由于气候原因,河源地区自行随意服用NSAIDs较多,春末和初秋的发病率高于其他季节。更多还原

【Abstract】 Objective:To investigate the epidemiological characteristics of perforated peptic ulcer in the Heyuan area,and to provide a theoretical basis for the prevention and treatment of the disease.Methods:To analyze the clinical data of 540 patients with PPU treated in Heyuan People’s Hospital from January,2007 to December,2010 with a retrospective study and to obtain the correlation factors of PPU.These factors including:sex,age,blood type,smoking,drinking,history of PU,treatment of PU,H.pylori status,NSAIDs use and seasons.Results:The ratio between PDU and PGU was 1.66∶1.The constituent ratio of blood type O was significantly higher than other blood types.The number of PGU patients of smokers was significantly higher than that in patients of non-smokers.The proportion of elders who were above 60 years old was higher than others.The patients of PPU were significant correlative with NSAIDS.The rate of H pylori infection was 80.74% among these patients.Incidences were different in seasons.Conclusion:Age,blood type O,smoking,NSAIDs and H.pylori infection are risk factors for PPU in Heyuan area.Many people had taken NSAIDs as one pleases for climate.Incidences was higher in late spring and early autumn.更多还原