【摘要】 目的通过对62例难治性癫痫患者进行前瞻性研究,对18F-FDG PET显像与脑电图(EEG)在颞叶癫痫致痫灶定位的诊断价值。方法对62例临床确诊颞叶癫痫并接受手术治疗的患者进行前瞻性研究。所有患者均进行发作间期PET/CT脑显像检查和长程或视频EEG检查,细致分析图像,并将所得检查结果与术后病理进行比较,利用统计学方法对二者的诊断准确率进行对比分析。结果 18F-FDG PET显像准确定位42例患者病灶位置,头皮EEG准确定位致痫灶30例,准确率分别为67.74﹪及48.39﹪,PET对癫痫的检出阳性率较头皮EEG高,两者比较差异有统计学意义(P<0.05)。18F-FDG PET显像结果表现较多样,影像分析应细致、审慎。结论发作间期PET/CT脑显像检查定位优于长程或视频EEG检查,但因其价格较昂贵,所以可首选EEG定位,EEG定位困难时才选择PET显像定位。更多还原

【Abstract】 Objective To prospectively evalue the efficacy of18F-FDG PET/CT brain imaging and electroencephalogram(EEG) in preoperative localization of temporal lobe epileptic focus in 62 patients.Methods 62 patients who were clinically diagnosed temporal lobe epilepsy and received surgical treatment were prospectively studied. All patients underwent interictal PET/CT brain imaging examination and long-range or video EEG examination prior to surgery. All the images were carefully analyzed and the test results obtained were compared with postoperative pathology. The diagnostic accuracy between the two methods were compared and analyzed using statistical methods. Results The rate of accurately locating epileptic focus was 67.74﹪(42/62)for PET/CT brain imaging and 48.39﹪(30/62)for long-range or video EEG, there was significant difference of accurate localization rate between the two methods(P <0.05). Conclusion Interictal PET/CT brain imaging is better than long-distance or video EEG examination in preoperative localization of temporal lobe epileptic focus. PET/CT brain imaging is too expensive, so EEG can be used as the preferred method in the clinical. PET imaging can significantly improve the rate of accurately locating epileptic focus when there are difficulties in the localization of temporal lobe epileptic focus with EEG.更多还原