【摘要】 目的评价替比培南匹伏脂的体外抗菌作用。方法用琼脂对倍稀释法测定替比培南匹伏脂对519株临床分离菌的体外抗菌活性。结果对革兰阳性球菌中的肺炎链球菌、化脓性链球菌及对甲氧西林敏感的金葡菌和凝固酶阴性的葡萄球菌,替比培南匹伏脂均显示良好的抗菌活性。尤其是对青霉素不敏感肺炎链球菌,替比培南匹伏脂的MIC50最低,为0.25 mg·L-1。本品对流感嗜血杆菌、卡他莫拉菌、产ESBLs和不产ESBLs的肺炎克雷伯菌和大肠埃希菌、易产诱导酶的阴沟肠杆菌、产气肠杆菌、枸橼酸杆菌、粘质沙雷菌的MIC50为≤0.03～5.00 mg·L-1,低于其他5种抗菌药物。结论替比培南匹伏脂对社区感染中常见病原菌有较好的抗菌活性。更多还原

【Abstract】 Objective To evaluate the in vitro activity of tebipenem pivoxil.Methods The minimum inhibitory concentrations(MICs) of tebipenem pivoxil against 519 strains of recent clinical isolates were determined and compared with selected comparators by means of agar dilution.Results For gram-positive aerobic pathogens,tebipenem pivoxil showed satisfied in vitro activity against methicillin susceptible Staphylococcus aureus(MSSA),methicillin susceptibel Staphylococcus coagulase negative(MSSCON),Streptococcus pneumoniae and Streptococcus pyogenes,especially in penicillin non-susceptible Streptococcus pneumoniae.MIC50 of tebipenem pivoxil(≤0.25 mg·L-1) was the lowest in 6 comparators.MIC90 of tebipenem pivoxil to Haemophilus influenzae,Moraxella catarrhalis,non-ESBLs Escherichia coli and Klebsielle,ESBLs Escherichia coli and Klebsielle,Enterobacter cloacae,Enterobacter aerogenes,Serratia marcescens,Citrobacter spp.were ≤0.03-0.50 mg·L-1.The antibacterial activity of tebipenem pivoxil showed the same or 1/4 MIC90 of meropenem,have good antibacterial activity for 4 comparators.Conclusion Tebipenem pivoxil is an effective antibiotic to common pathogenic bacteria infection in the community.更多还原