【摘要】 目的评价右美托咪定对病态肥胖的阻塞性睡眠呼吸暂停综合征患者血气分析的影响。方法 40例ASAⅢ级欲行悬雍垂腭咽成形术的病态肥胖的阻塞性睡眠呼吸暂停综合征患者,随机分成右美托咪定组和安慰剂组,右美托咪定组给予负荷剂量1μg·kg-1(20 min)的右美托咪定,安慰剂组则给予容量和外形相似的生理盐水。观察用药后患者的血流动力学及用药前后血气分析的变化。结果右美托咪定组20 min后的心率(HR)、平均血压(BP)、血氧分压(PaO2)与安慰剂组相比显著降低;二氧化碳分压(PaCO2)及pH值与安慰剂组相比差异无统计学意义。结论短时间内大剂量的右美托咪定应用于病态肥胖的阻塞性睡眠呼吸暂停综合征患者也可以产生呼吸抑制。更多还原

【Abstract】 Objective To assess the effect of dexmedetomidine on the hemodynamics and blood gas analysis in morbidly obese patients with obstructive sleep apnea.Methods Forty patients scheduled for uvulopalatopharyngoplasty were randomized assigned into receive dexmedetomidine group or placebo group,respectively.In dexmedtomidine group patients received a loading dose of dexmedetomidine 1 μg·kg-1 during 20 minutes,In placebo group patients received a volume matched 0.9% saline.Heart rate(HR),blood pressure(BP) and blood gas analysis were monitored.Results HR,mean arterial blood pressure and arterial PaO2 presented a statistically significant reduction in the dexmedetomidine group after 20 minutes as compared to the placebo group.Blood PaCO2 and pH were similar for both groups.Conclusion Dexmedetomidine produced respiratory depression in morbidly obese patients with obstructive sleep apnea.更多还原