【摘要】 目的评价阿立哌唑与喹硫平治疗精神分裂症的疗效及安全性。方法169例符合DSM-Ⅳ(第4版)精神分裂症患者,阿立哌唑组79例,剂量10～30mg·d-1;喹硫平组90例,剂量400～750 mg·d-1,疗程均8周。治疗前,治疗第4,8周用阳性和阴性症状量表(PANSS)评价主要疗效。用实验室检查、生命体征、心电图等评价安全性。结果 2组治疗4,8周PANSS总分均较治疗前有显著下降(P均<0.01),治疗8周末,PANSS总分减分差值及疗效2组间差异无统计学意义。2组药物不良反应发生率分别为25.3%(20/79)和17.7%(16/90)。阿立哌唑组对心率的影响较喹硫平组小;阿立哌唑组甘油三酯水平和心电图QRS间期较治疗前变化明显(P<0.05)。喹硫平组心率、体重、体重指数、血红蛋白、总胆固醇和低密度脂蛋白较治疗前变化明显(P<0.01)。结论阿立哌唑与喹硫平对精神分裂症疗效相当,两者所致不良反应发生率相近。更多还原

【Abstract】 Objective To investigate the clinical efficacy and safety of aripiprazole and quetiapine in the treatment of schizophrenia.Methods A randomized,controlled clinical trial was designed.One hundred and sixty-nine patients with schizophrenia were randomized into aripiprazole group(n=79,8 weeks,10-30 mg·d-1) and quetiapine group(n=90,8 weeks,400-750 mg·d-1).The positive and negative syndrome scale(PANSS) and response rate were mainly used to evaluate efficacy.The safety was assessed by using the laboratory examination,vital signs and electrocardiogram(ECG) at the baseline,week 4,8.Results Compared with the baseline,total scores of PANSS in both groups decreased significantly at week 4 and week 8(P<0.01).At week 8 of treatment the mean reduction scores of PANSS and the clinical response rates were approximate,there were no significant differences between both groups.The incidence of adverse drug reactions related to the drugs 25.3%(20/79) in aripiprazole and 17.7%(16/90)in quetiapine treatment was approximate in both groups,with lower liability for heart rate in aripiprazole than in quetiapine treatment.The triglyceride(TG) and QRS interval in aripiprazole group showed more significant differences at week 8 than the baseline(P<0.05).But the heart rate,body mass,body mass index(BMI),hemoglobin(HGB),total cholesterol(TC)and low density lipoprotein(LDL) in quetiapine group different significantly when compared with those at baseline(P<0.01).Conclusion Aripiprazole and quetiapine both have good efficacy in the treatment of schizophrenia.They have similar incidence of adverse drug reaction related to the drugs.更多还原