【摘要】 目的评价阿立哌唑与氯丙嗪治疗精神分裂症的不良反应的差异。方法检索国内阿立哌唑与氯丙嗪对照研究治疗精神分裂症的文献,用系统评价方法对10篇文献评估。结果药物不良反应发生率2组差异有统计学意义(P<0.05)。其中,发生头痛、失眠,阿立哌唑组明显比氯丙嗪组多(P<0.05);发生口干、震颤、静坐不能、肌强直、便秘、肝功能异常、心动过速、体重增加、直立性低血压、视物模糊、嗜睡、心电图异常、月经失调、溢乳不良反应,氯丙嗪组明显比阿立哌唑组多(P<0.05)。结论阿立哌唑组发生不良反应的总体风险低于氯丙嗪。更多还原

【Abstract】 Objective To study the difference in adverse drug reaction(ADR) between aripiprazole and clorpromazine in the treatment of schizophrenia.Methods A total of 10 paper about control study comparing aripiprazole with clorpromazine in treatment of schizophrenia retrieved were subjected to system evaluation.Results There was significant difference in ADR incidences between the two groups(P<0.05).The incidences of ADR(such as headache insomnia) in aripiprazole group were significantly higher than in clorpromazine group(P<0.05).The incidences of ADR(such as dry mouth,tremor,akathisia,rigidity,constipation,abnormal,liver function,tachycardia,weight gain,orthostatic hypotension,blurred vision,drowsiness,menstruation disturbance syndrome) in clorpromazine group were significantly higher than in aripiprazole group(P<0.05).Conclusion Aripiprazole has less overall risk of ADR than clorpromazine for the treatment of schizophrenia.更多还原