【摘要】 目的探讨高同型半胱氨酸(Hcy)血症与原发性高血压患者左室舒张功能不全的相关性。方法用循环酶法测定高血压患者80例[非左室肥厚组(NLVH)40例,左室肥厚组(LVH)40例]和40例健康者血清Hcy水平,并用超声心动图测量左室心肌质量指数(LVMI)、二尖瓣舒张早期流速峰值(EPFV)、晚期流速峰值(APFV)及峰值比(E/A)。结果对照组、NLVH组和LVH组血清Hcy水平分别为(9.17±1.68)、(19.52±2.76)、(25.93±3.93)μmol/L,E/A比值分别为(1.20±0.40)、(0.82±0.34)、(0.66±0.30),每两组比较差异均有统计学意义(P<0.01或0.05)。LVMI与血清Hcy水平呈正相关(r=0.482,P<0.01),E/A比值则与血清Hcy水平呈负相关(r=-0.413,P<0.01)。结论高Hcy血症与高血压患者的左室肥厚及左室舒张功能密切相关。更多还原

【Abstract】 Objective To investigate the association between hyperhomocysteinemia and left ventricular diastolic function in patients with hypertension. Methods Serum homocysteine (Hcy) level in 80 essential hypertension patients including 40 non-left ventricular hypertrophy (NLVH) and 40 left ventricular hypertrophy (LVH) cases and 40 healthy controls was detected by enzymatic cycling assay. LVMI, EPFV, APFV and E/A ratio were examined by echocardiogram. Results Serum Hcy level was (9.17±1.68) μmol/L in control group, (19.52±2.76) μmol/L in NLVH group and (25.93±3.93) μmol/L in LVH group, and significant difference was present between three groups (P<0.01). There were a positive correlation between LVMI and Hcy level (r=0.482, P<0.01) and a negative correlation between E/A ratio and Hcy content (r=-0.413, P<0.01). Conclusion Hyperho-mocysteinemia is closely related to left ventricular hypertrophy and diastolic function in hypertension patients.更多还原